２．エピジェネティクスEpigenetics　　　powered by  Open政塾 実戦英語 　

　　　　

 Open政塾は誰でも無料で参加できる時間・場所の制限のない実戦英語の学習場です。実戦英語ではビジネスマン・研究者が仕事に役立つ英語力を鍛えるのが目標です。ブログDRMASSA's fathomで学習支援します。


           Deep dive: Epigenetics Clock
日本は長寿国ですが、健康寿命は伸び悩んでいるようです。世界中のGenetics Epigeneticsの研究機関でanti-ageingに役立つ知見が急速に積みあがっています。最新論文のabstract部分だけ速読したいというニードに応えます。この分野は、起業機会が豊富です。あなたも異業種参入の機会をさぐりませんか？

Genetics Epigeneticの分野では単語力の増強がMUSTです。論文に挑戦する前に、平易な解説で有名なDr.Rhonda Patrickの解説動画および体験談の動画を選んで、聞き流し理解できるまでproficiencyを高めましょう, それがGP＝3 Aレベルです。
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Notice: Class will meet  8am Sunday, April 26.     

            Will discuss Epigenetic Clock　

            Watch 3 Video presentations in the following sequence:

 　　　　1.  What is epidemics  by Dr. Carlos Guerrero-Bosagna            ( 5 minutes 2020)

         2.  Epidemic Aging How old is your DNA    Dr. Rhonda Patric      ( 4 minutes 2020)

         3．Is Epigenetic Clock  Reversible?  The Sheekey Science Show    (10 minutes 2019)


 

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  Class mat / hand outs

テーマ：エピデミクス

1.  What is epidemics  by Dr. Carlos Guerrero-Bosagna            ( 5 minutes 2020)
  おなじDNAから生まれた（同じゲノム）双子の一方が、心臓病を発症し、片方はマラソンを走っている、この差はどこから来るのでしょう？大人になるにつれてエピゲノムが少しずつ変化していったのです。同じゲノムでも細胞ごとに異なるエピゲノムがあるというわけです。生育環境要因が、DNAに働きを制御するタグ付けをして、個体ごとに異なる体を作るエピゲノムを平易に説明しています。日本語訳語もエピゲノムです。
1;22  The most common way interference happens is that DNA, or the proteins it's wrapped around,  get labeled with small chemical tags.  The set of all of the chemical tags that are attached to the genome of a given cell is called the epigenome.  Some of these, like methyl group, inhibit gene expression by derailing the cellular transcription machinery, or causing the DNA to coil more tightly, making it inaccessible.  The gen is still there, but it's silent.  Boosting transcription is essentially the opposite. Some chemical  tags will unwind the DNA, making it easier to transcribe, which ramps up production of the associated protein.  Epigenetic changes can survive cell division, which means they could affect an organism for its entire life.  Sometimes that's a good thing.  Epigenetic changes are part of normal development, the cells in an embryo start with one master genome.  As the calls divide, some gens are activated and other inhibited.  Overtime, through this epigenetic reprogramming, some cells develop into heart cells, and other into liver cells.  　　　　　
 

2. Epigenetic Aging  How old is your DNA?        3:45 2020/12/16
ゲノム時計（DNA時計）　と　　エピジェネティック時計　　老化の進み具合がわかる
0:59  As you age, the methylation of your DNA changes in a predictable way - like clockwork.  The speed of this 'epigenetic clock' is slightly different for everyone - depending on your individual genetics, and to a lesser extent, lifestyle.  Dr. Steve Horvath was among the first to create a test to measure someone's epigenetic age.  the Horvath clock.  The Horvath Clock's breakthrough was that it can accurately measure how old someone is - to within 3.6 years - just by looking at their DNA.  But epigenetic age could tell us a lot more - it could be an indication of true biological age.  We use the term 'Epigenetic age acceleration' to describe when your DNA seems older than you are.  And by comparing the age of different organs in someone's body, you might be able to find out which ones are aging faster or slower.  One of Dr. Horvath's more recent clocks - the GrimAge clock - can predict the risk of cancer, heart disease, and death in general.  

3．Is Epigenetic Clock  Reversible?  The Sheekey Science Show    (10 minutes 2019)
エピジェネティック時計を遅らせることができたという実験結果が出ています。老化が進むのを遅らせる？　老化時計を逆さに回して、Life Spanを伸ばせるのか？
6：49 Given that we can measure the methylation status and we know the epigenetic marks can be reversed the epigenegic age so as I mentioned earlier in this video this paper* seems to be the first report of an increase in predicted human lifespan by currently accessble aging interventions and they have evidence . They have in theory reverse the epigenetic age so what they actually did. *:Reversal of ipigenetic aging and immunosenescent trend in humans    There's the paper they set up this trend trying trais, right? trying to speak with with stands for the thymus regeneration immune arrest arranged in an insulin might occatsion and they did this in a select group of healthy men aged between 51 and to 65 years and then used a recombinant growth hormone t try to prevent or even what they say to reverse the aging by regenerating and restoring the tymus.  So why the tymus, one ofthe characteristics of the ageing process seems to be thymic in pollution literally shrinking of of the fhymus and
this has the consequences of reducing the immune cell population and so thymic pollution is linked to age-related increases in cancer incidents autoimmune diseases inflammation antheroscleroisis. And all cause mortality and its even  been seen that centenarians have maintained an immune function so by targeting the thymus it possible tat you kids prevent or slow down the ageing process and as said they used human growth hormone to do this but because this has a consequence of inducing hyper pedemia they they also used two other compounds metformin and DHEA as well to try and counteract this effect or they metformin for example is also known to maybe have anti-aging effects and in this trial, they used four different EPI two clocks to give a readout or measurement epigenetic age to correlate it with the chronological age.  
So firstly it's important to notice that they saw that the epigenetic age was lower than the chronological age hence the negative scale and the axes and interestingly what they saw was that in all of the different age estimators that they used the rate of aging regression accelerated after nine months of treatment so obviously epigenetic age doesn't include all aspects of aging but since it's currently our best measure of biological age is interesting and exciting to see these kind of results  The question  that they're growing now is what is the mechanism of this reversal and what actually is the causes of the changes in the first place. So yes this is a huge topic but it gives hope that were were slowing the process  of aging. Could it be possible for altering epigenetic marks?  



Pre-class work required
EpigeneticClock老化時計とEpigenetic intervention for reverse agingのテーマの最新論文　１件を検索して、abstractを読みます。
クラスで発表します。
 

 

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DRMASSA拝

Epi Clock